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Filtered Search Results
AMBEED
NC4004586 DANGLIPR CAS2230198-02-2 200MG
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AMBEED
NC4024441 BUTYL ISO CARBO 5G
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CHEM IMPEX INTL INC
NC4029543 7-AZABENZOTRIAZOL-1 25G
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MEDCHEMEXPRESS LLC Sulfo-ara-F-NMN | 1374663-29-2 | 99.4% | 25 MG
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Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN) that selectively activates SARM1 and inhibits CD38 with an IC50 of approximately 10 μM. This compound stimulates intracellular cyclic ADP-ribose (cADPR) production and subsequently activates SARM1 to generate cyclic ADP-ribose, leading to non-apoptotic cell death. It is intended for research use only.
- Mimetic of nicotinamide mononucleotide (NMN)
- Selectively activates SARM1
- Inhibits CD38 (IC50 around 10 μM)
- Induces intracellular cyclic ADP-ribose (cADPR) production
- Activates SARM1 to produce cyclic ADP-ribose
- Induces non-apoptotic cell death
- For research use only
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MEDCHEMEXPRESS LLC Amino-PEG5-amine | 72236-26-1 | 97.0% | 5 G
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Amino-PEG5-amine is a PEG-based (5 units) PROTAC linker, appearing as a colorless to light yellow liquid. With a molecular weight of 280.36 and a formula of C12H28N2O5, it is soluble in water (≥ 100 mg/mL). This compound is suitable for research use only.
- Used in the synthesis of PROTACs
- Appears as a colorless to light yellow liquid
- Soluble in water (≥ 100 mg/mL)
- For research use only
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MEDCHEMEXPRESS LLC Sapitinib | 848942-61-0 | 200 MG
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Sapitinib (AZD-8931) is a reversible, ATP competitive EGFR inhibitor with IC50s of 4, 3, and 4 nM for EGFR, ErbB2, and ErbB3 in cells, respectively. It demonstrates potent inhibitory effects on erbB2 in ligand-independent MCF-7 cl24 cells, significantly inhibits Akt phosphorylation, and induces apoptosis in human IBC cells.
- Reversible, ATP competitive EGFR inhibitor
- Potent inhibitory effect on erbB2 in ligand-independent MCF-7 cl24 cells
- Significantly inhibits phosphorylation of Akt in SUM149 and FC-IBC-02 cells
- Inhibits proliferation and induces apoptosis in human IBC cells
- Active in xenograft tumor models responsive to EGFR inhibition alone or EGFR or erbB2 inhibition
- Causes pharmacodynamic changes in proliferation and apoptosis markers in human tumor xenograft models
- Favorable oral pharmacokinetics in rat and dog
- Low human hepatocyte turnover
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MEDCHEMEXPRESS LLC 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-amine | 211859-73-3 | 97.0% | 1 G
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m-PEG9-Amine is a versatile PEG-based linker. It functions as a PROTAC linker, facilitating the synthesis of Proteolysis-Targeting Chimeras (PROTACs). Additionally, it serves as a cleavable ADC linker, crucial for the synthesis of antibody-drug conjugates (ADCs).
- Functions as a PEG-based PROTAC linker
- Enables the synthesis of Proteolysis-Targeting Chimeras (PROTACs)
- Acts as a cleavable ADC linker
- Essential for the synthesis of antibody-drug conjugates (ADCs)
- Utilizes the intracellular ubiquitin-proteasome system for targeted protein degradation
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MEDCHEMEXPRESS LLC Amino-PEG8-amine | 82209-36-7 | ≥98.0% | 1 G
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Amino-PEG8-amine is a PEG-based (8 units) PROTAC linker that can be used in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker; one ligand is for an E3 ubiquitin ligase, and the other is for the target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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MEDCHEMEXPRESS LLC DCZ0415 | 2242470-43-3 | 99.8% | 200 MG
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DCZ0415 is a potent TRIP13 inhibitor that impairs nonhomologous end joining repair and inhibits NF-κB activity. It induces anti-myeloma activity in vitro, in vivo, and in primary cells derived from drug-resistant myeloma patients.
- Significantly decreases colony formation
- Inhibits cell proliferation
- Decreases viability in MM cells
- Induces apoptotic cell death
- Causes accumulation of MM cells in G0/G1 phase
- Decreases protein levels of phosphorylated iκBα and NF-κB
- Exerts cytotoxic effects by inhibiting DNA synthesis
- Reduces growth of MM cells-induced tumors in immune-deficient mice
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MEDCHEMEXPRESS LLC MCC950 | 210826-40-7 | 99.8% | 200 MG
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MCC950 is a potent and selective NLRP3 inhibitor, with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs. It blocks canonical and non-canonical NLRP3 activation at nanomolar concentrations. This product is for research use only.
- Potent and selective NLRP3 inhibitor
- Blocks canonical and non-canonical NLRP3 activation
- Specifically inhibits NLRP3, not AIM2, NLRC4, or NLRP1
- Reduces interleukin-1β (IL-1β) production
- Attenuates the severity of experimental autoimmune encephalomyelitis (EAE)
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MEDCHEMEXPRESS LLC Liproxstatin-1 | 950455-15-9 | 99.70% | 200 MG
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Liproxstatin-1 is identified as a potent ferroptosis inhibitor, effectively suppressing ferroptotic cell death with an IC50 value of 22 nM. It demonstrates anti-ferroptotic activity across various cell types, including fibroblasts, lymphocytes, and mouse embryonic fibroblasts (MEFs). Studies have also indicated its ability to suppress ferroptosis in vivo, specifically in human cells, Gpx4 deficient kidney cells, and in an ischemia/reperfusion-induced tissue injury model.
- Potent ferroptosis inhibitor.
- Inhibits ferroptotic cell death with an IC50 of 22 nM.
- Shows anti-ferroptotic activity in mouse embryonic fibroblasts with an IC50 of approximately 38 nM.
- Suppresses ferroptosis in human cells.
- Suppresses ferroptosis in Gpx4 deficient kidney.
- Suppresses ferroptosis in an ischemia/reperfusion-induced tissue injury model.
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MEDCHEMEXPRESS LLC Rivastigmine (tartrate) | 129101-54-8 | MFCD03700731 | 99.03% | 400.42 | 50 MG
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Rivastigmine tartrate is an orally active and potent cholinesterase (ChE) inhibitor. It inhibits butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). This compound can pass the blood-brain barrier (BBB) and is used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.
- Orally active and potent cholinesterase (ChE) inhibitor
- Inhibits butyrylcholinesterase (BChE) and acetylcholinesterase (AChE)
- Can pass the blood-brain barrier (BBB)
- Used for research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease
- Reduces LPS-induced TNF-α and IL-6 in vitro
- Improved behavioral impairments caused by Aluminum in male Wistar albino rats
- Reduced IL-6 concentration in BALB/c OlaHsd male mice with acute colitis
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MEDCHEMEXPRESS LLC hsa-miR-31-5p mimic 5nmol | 5nmol
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hsa-miR-31-5p mimics are small chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity
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MEDCHEMEXPRESS LLC IDELALISIB 200 mg
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IDELALISIB 200MG
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MEDCHEMEXPRESS LLC hsa-miR-31-5p mimic 20nmol | 20nmol
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hsa-miR-31-5p mimics are small chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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